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Animal-free Recombinant Human IL-9 is expressed from human 293 cells as a glycoprotein monomer with apparent molecular mass of 38 to 48 kDa. IL-9 is produced in a human cell expression system with serum-free, chemically defined media. It stimulates cell proliferation and also prevents apoptosis. IL-9 acts as a regulator for a variety of hematopoietic cells. It enhances the expansion and recruitment of mast cells and eosinophils. This cytokine is greater than 95% pure.
Interleukin 9 (IL-9) is a γc-family cytokine produced by T-helper 9 (Th9) cells. IL-9 promotes the survival and activation of various cellular targets, including mast cells, B cells, T cells, and structural cells. Its expression is considered a hallmark of Th2-lineage cells. Primarily studied in Th2-type immunity, IL-9 was shown to be involved in asthma, allergy, and host defense against helminth infections. IL-9 also stimulates cell proliferation and prevents apoptosis. It functions through the its cognate receptor (IL9R), which activates different signal transducer and activator proteins to execute various biological processes (PMID: 29703631; 29437190; 29392411; 29391143)