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CtIP antibody (mAb) (Clone 14-1)

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

ChIP, ICC, IF, IP, WB

CloneNo.

14-1

Cat No : 61141,61142,61942 61141

Synonyms

CtIP, CTBP interacting protein, RBBP8, RIM, COM1, transcriptional regulator, tumor suppressor, C-Terminal Binding Protein, Rb, repressor, TFIID, TFIIB, p130, Ikaros, DNA, brca1, cancer, monoclonal, clone 14-1, sample

验证数据展示

  • CtIP antibody mpAb) tested by Western blot 20 ug of HEK293 whole cell extract was run on SDS-PAGE and probed with antibody at 1 ug/ml.

    CtIP antibody mpAb) tested by Western blot 20 ug of HEK293 whole cell extract was run on SDS-PAGE and probed with antibody at 1 ug/ml.

产品信息

Tested Applications ChIP, ICC, IF, IP, WB

Applications Validated by Active Motif: WB: 1 - 2 ug/ml
Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen This CtIP antibody was raised against a recombinant protein corresponding to amino acid residues 620-897 of human CtIP.
Full Name CtIP antibody (mAb) (Clone 14-1)
Synonyms CtIP, CTBP interacting protein, RBBP8, RIM, COM1, transcriptional regulator, tumor suppressor, C-Terminal Binding Protein, Rb, repressor, TFIID, TFIIB, p130, Ikaros, DNA, brca1, cancer, monoclonal, clone 14-1, sample
Molecular weight 120 kDa
GenBank accession numberNP_002885
RRIDAB_2714164
Purification Method Protein A Chromatography
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

背景介绍

CtIP (CTBP interacting protein, RBBP8, RIM, COM1) is a transcriptional regulator and tumor suppressor first identified through its interaction with CTBP (C-Terminal Binding Protein). CtIP binds to the Rb protein and serves as a transcriptional repressor, through recruitment of CtBP and also by interaction with general transcription factors TFIID and TFIIB. CtIP also interacts with Rb-related protein p130 and Ikaros, a master regulator in lymphocyte development. CtIP is phosphorylated upon DNA damage (likely by ATM and/or ATR), interacts with BRCA1 and plays a critical role in facilitating DNA damage repair. Mutations that abolish the interaction between CtIP and BRCA1 result in loss of cell cycle control leading to the development of cancer.