NeutraKine®系列中和抗体

中和抗体在病毒学、细胞因子和生长因子的研究中至关重要。细胞培养中添加中和抗体可以特异性地阻断其靶标蛋白的生物活性,从而分离特定蛋白质。

Proteintech的NeutraKine®系列中和抗体是采用HumanKine®人源细胞表达的细胞因子和生长因子作为免疫原制备的,因此它们是通过了人源真核蛋白质的检测,具有优异的中和活性和生物效应。

NeutraKine®系列中和抗体

用于细胞因子和生长因子中和作用的临床前研究和学术研究的理想抗体。

NeutraKine® 系列对照抗体

NeutraKine® 系列对照抗体同样是以HumanKine®系列活性蛋白作为原料开发而来,但因为结合到不同的位点,所以不表现出中和活性。这些对照抗体有助于排除中和试验中的非特异性效应。

NeutraKine®系列中和抗体可以做什么?

阻断细胞因子/生长因子的作用

证明目标蛋白的存在

研究靶蛋白的功能

研究生物过程的机理

评估药物开发的可能性

TF-1 human erythroleukemic cells proliferate in response to stimulation by HumanKine® beta NGF (HZ-1222, green line). The stimulation response from HZ-1222 (4ng/mL) is neutralized by increasing concentration of NeutraKine™ beta NGF antibody (69009-1-IG, blue line) and leading competitor’s antibody (brown line). The ND50 of 69009-1-IG is over 100X lower than the leading competitor’s antibody.

Comparison of neutralizing activity of NeutraKine™ products against leading competitor in parallel assays

Target Fold stronger neutralization Proteintech ND50 (ng/mL) Leading competitor ND50 (ng/mL)
Beta-NGF 100X 17.3 1700
IL-3 12.5X 0.8 10
IL-6 6.5X 6.3 41

  1. NeutraKine®系列中和抗体均采用具有真实活性的HumanKine®人源活性蛋白质作为免疫原,使抗体能更好地与天然形式的靶蛋白反应。
  2. HumanKine活性蛋白产品在市场上可售,可配合中和抗体使用。
  3. NeutraKine®系列中和抗体都经过Proteintech全自主的、真实的生物活性检测,每一个产品都提供严格的中和试验检测数据。
  4. NeutraKine®系列中和抗体均以无菌冻干形式提供,除PBS外无其他添加物(不含叠氮化物、不含甘油、不含海藻糖),内毒素含量超低。
  5. NeutraKine®系列中和抗体都能与靶蛋白表面的功能区域反应,可用于液相中的反应应用,如夹心ELISA、化学发光、免疫层析。

NeutraKine™ and NeutraControl™ antibodies

Target Type ND 50
beta NGF Mouse Monoclonal 4-20 ng/mL ( in the presence of 2 ng/mL HZ-1222)
BMP-4 Mouse Monoclonal 3-10 μg/mL ( in the presence of 200 ng/mL HZ-1045)
BMP-7 Mouse Monoclonal 1-2 μg/mL ( in the presence of 200 ng/mL HZ-1229)
Cystatin C Mouse Monoclonal 0.5 mg/mL (in the presence of 0.4 μg/mL HZ-1211)
EPO Mouse Monoclonal 2-5 μg/mL (in the presence of 6 ng/mL HZ-1168)
FGF 4 Mouse Monoclonal 0.1-0.4 μg/mL (in the presence of 2ng/mL HZ-1218)
FGFBasic-TS Mouse Monoclonal 1-10 μg/mL ( in the presence of 0.1 ng/mL HZ-1285)
GM-CSF Mouse Monoclonal 1.5-4 μg/mL ( in the presence of 0.2 ng/mL HZ-1002)
IFN alpha 2A Mouse Monoclonal 300-500 ng/mL (in the presence of 100 ng/mL HZ-1066)
IFN beta Mouse Monoclonal 5-20 ng/mL ( in the presence of 10 ng/mL IFN beta)
IFN gamma Mouse Monoclonal 100-400 ng/mL ( in the presence of 5 ng/mL HZ-1301)
IL-10 Mouse Monoclonal 50-200 ng/mL ( in the presence of 10 ng/mL HZ-1145)
IL-17A Mouse Monoclonal 200-600 ng/mL ( in the presence of 40 ng/mL HZ-1113)
IL-17F Mouse Monoclonal 2-8 μg/mL (in the presence of 500 ng/mL HZ-1116)
IL-23 p40 Mouse Monoclonal 8-30 ng/mL ( in the presence of 4 ng/mL HZ-1254)
IL-3 Mouse Monoclonal 0.8-2.4 ng/mL (in the presence of 0.5 ng/mL HZ-1074)
IL-4 Mouse Monoclonal 200-500 ng/mL ( in the presence of 0.5 ng/mL HZ-1004)
IL-6 Mouse Monoclonal 3-15 ng/mL ( in the presence of 1 ng/mL HZ-1019)
Noggin Mouse Monoclonal 5-20 μg/mL ( in the presence of 80 ng/mL HZ-1118 and 20 ng/mL BMP-4)
PDGFbb Mouse Monoclonal 20-50 μg/mL ( in the presence of 20ng/mL HZ-1308)
TGF beta 1 Mouse Monoclonal 0.5-2 μg/mL ( in the presence of 0.03 ng/mL HZ-10111)
Thrombin Mouse Monoclonal 5-20 μg/mL (in the presence of 400 ng/mL HZ-3010)
TNF alpha Mouse Monoclonal 10-50 ng/mL ( in the presence of 0.05 ng/mL HZ-1014)
VEGF165 Mouse Monoclonal 200-600 ng/mL ( in the presence of 10 ng/mL HZ-1038)
Target Type ND 50
EPO Mouse Monoclonal 0.019-80 μg/mL (in the presence of 1 ng/mL HZ-1168)
IFN gamma Mouse Monoclonal 0.00244-40 μg/mL ( in the presence of 5 ng/mL HZ-1301)
IL-10 Mouse Monoclonal 7.8125-2000 ng/mL ( in the presence of 10 ng/mL HZ-1145)
IL-17A Mouse Monoclonal 0.3051-5 μg/mL ( in the presence of 40 ng/mL HZ-1113)
IL-23 Mouse Monoclonal 0.244-4000 ng/mL ( in the presence of 4 ng/mL HZ-1254)
IL-6 Mouse Monoclonal 0.06-1000 ng/mL ( in the presence of 1 ng/mL HZ-1019)
Noggin Mouse Monoclonal 0.0244-200 μg/mL ( in the presence of 40 ng/mL HZ-1118 and 20 ng/mL BMP-4)
PDGFbb Mouse Monoclonal 3.125-200 μg/mL ( in the presence of 20ng/mL HZ-1308)
TNF alpha Mouse Monoclonal 0.128-10000 ng/mL ( in the presence of 0.05 ng/mL HZ-1014)
VEGF165 Mouse Monoclonal 0.00244-40 μg/mL ( in the presence of 10 ng/mL HZ-1038)
Target Type ND 50
BMP-4 Mouse Monoclonal 3-10 ug/mL (in the presence of 200 ng/mL HZ-1045)
BMP-7 Mouse Monoclonal 1-2 ug/mL (in the presence of 200 ng/mL HZ-1229)
Cystatin C Mouse Monoclonal 0.5 mg/mL (in the presence of 100 ug/mL HZ-1211)
Noggin Mouse Monoclonal 5-20 ug/mL (in the presence of 20 ng/mL HZ-1045) 
TGF beta 1 Mouse Monoclonal 0.5-2 ug/mL (in the presence of 0.03 ng/mL HZ-1011)
Target Type ND 50
GM-CSF Mouse Monoclonal 1.5-4 µg/mL (in the presence of 0.2 ng/mL HZ-1002)
Target Type ND 50
IL-3 Mouse Monoclonal 0.8-2.4 ng/mL(in the presence of 0.5 ng/mL HZ-1074)
IL-4 Mouse Monoclonal 200-500 ng/mL(in the presence of 0.5 ng/mL HZ-1004)
IL-6 Mouse Monoclonal 3-15 ng/mL (in the presence of 1 ng/mL HZ-1019)
IL-10 Mouse Monoclonal 50-200 ng/mL (in the presence of 10 ng/mL HZ-1145)
IL-17A Mouse Monoclonal 200-600 ng/mL (in the presence of 40ng/mL HZ-1113) 
IL-17F Mouse Monoclonal 2-8 μg/mL (in the presence of 500 ng/mL HZ-1116)
IL-23 p40 Mouse Monoclonal 8-30 ng/mL(in the presence of 4 ng/mL HZ-1254)
IFN alpha 2A Mouse Monoclonal 300-500 ng/mL(in the presence of 100 ng/mL HZ-1066)
IFN beta Mouse Monoclonal  5-20 ug/mL (in the presence of 10 ng/mL HZ-1298)
IFN gamma Mouse Monoclonal 100-400 ng/mL(in the presence of 5 ng/mL HZ-1301)
TNF-alpha Mouse Monoclonal 10-50 ng/mL (in the presence of 0.05 ng/mL HZ-1014)
Target Type ND 50
Beta-NGF Mouse Monoclonal 4-20 ng/mL(in the presence of 2 ng/mL HZ-1222)
EPO Mouse Monoclonal 2-5 ug/mL (in the presence of 6 ng/mL HZ-1168)
FGF-4 Mouse Monoclonal  0.1 -0.4ug/mL (in the presence of 2ng/mL HZ-1218)
FGFBasic-TS Mouse Monoclonal 1-10 μg/mL ( in the presence of 0.1 ng/mL HZ-1285)
PDGF-BB Mouse Monoclonal 20-50 ug/mL (in the presence of 20 ng/mL HZ-1308)
Thrombin Coagulation Factor II Mouse Monoclonal 5-20 ug/mL (in the presence of 400 ng/mL HZ-3010)
VEGF165 Mouse Monoclonal 200-600 ng/mL ( in the presence of 10 ng/mL HZ-1038)