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NeutraKine® BMP-4 Monoclonal antibody

NeutraKine® BMP-4 Monoclonal Antibody for ELISA, Neutralization

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

ELISA, Neutralization

Conjugate

Unconjugated

CloneNo.

3B5A7

Cat no : 69015-1-Ig

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Synonyms

BMP 2B, BMP 4, BMP2B, BMP2B1, BMP4, BMP-4, Bone morphogenetic protein 2B, bone morphogenetic protein 4, DVR4, MCOPS6, NeutraKine® BMP-4, ZYME

验证数据展示

  • Neutralization experiment of NeutraKine® BMP-4 using 69015-1-Ig

    Neutralization experiment of NeutraKine® BMP-4 using 69015-1-Ig

    Recombinant human BMP-4 (Cat.NO. HZ-1045) induces alkaline phosphatase production in the ATDC-5 cell line (using pNPP as chromogenic substrate for detection) in a dose dependent manner (blue curve, bottom X-left Y). The activity of human BMP-4 (200 ng/mL HZ-1045) is neutralized by mouse anti-human BMP-4 antibody 69015-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 3-10 μg/mL.

Planning an IHC experiment? We recommend our IHCeasy BMP4 Ready-To-Use IHC Kit. BMP4 primary antibody included.
Neutralization

产品信息

69015-1-Ig targets NeutraKine® BMP-4 in ELISA, Neutralization applications and shows reactivity with Human samples.

Tested Applications ELISA, Neutralization Application Description
Tested Reactivity Human
Immunogen human Humankine BMP-4 protein HZ-1045 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name bone morphogenetic protein 4
Synonyms BMP 2B, BMP 4, BMP2B, BMP2B1, BMP4, BMP-4, Bone morphogenetic protein 2B, bone morphogenetic protein 4, DVR4, MCOPS6, NeutraKine® BMP-4, ZYME
Gene Symbol BMP4
Gene ID (NCBI) 652
RRIDAB_2918836
Conjugate Unconjugated
Form Lyophilized Powder
Purification MethodProtein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

背景介绍

BMP4, also named as BMP2B and DVR4, belongs to the TGF-beta family. BMPs have been shown to promote astroglial differentiation both in vitro and in vivo. BMP4 have been shown to be components of serum and are thought to be responsible for this differentiation. BMP4 are expressed mainly in neurons, with minimal expression detected in astrocytes and oligodendrocytes.

This antibody can be used to neutralize the bioactivity of BMP-4.