细胞因子&活性蛋白

人源细胞(HEK293)表达的细胞因子&活性蛋白具有高生物活性、高稳定性、批次间的高度一致性,更接近天然人源蛋白的构象和翻译后修饰。

我们的人源表达系统确保蛋白质具有天然构象和翻译后修饰,以优化生物活性。无标签,没有异源成分。

不含动物成分

无内毒素

无异源成分

无标签

无载体

HumanKine®重组蛋白是在HEK293细胞中产生的,无动物成分

细菌表达的蛋白质不具有翻译后修饰,例如磷酸化或糖基化。就活性而言,许多蛋白质需要糖基化和加工,这只能在真核系统中实现;特别是人源细胞表达系统,可以获得真正的人类蛋白质。

所有Humankine®重组蛋白均在Proteintech的cGMP级实验室生产,遵守严格的质量控制规定。

  • 真正的人源蛋白质

  • 天然构象与翻译后修饰

  • 高生物活性和稳定性

  • 从研究到cGMP的无缝过渡

为了促进从临床前到临床的平稳过渡,Humankine®提供了一系列仅用于研究(RUO)和cGMP级重组蛋白质,这些蛋白质从HEK293人类细胞中表达和纯化。RUO和cGMP产品均生产于cGMP标准车间,使用相同的表达系统、生产流程和操作程序,保证了这些产品质量和性能的一致性。

我们的cGMP产品与RUO的关键区别在于,我们坚持严格的质量流程,通过ISO13485认证并符合cGMP标准。cGMP级产品附带大量文件、全面的质量检监测和可追溯性。RUO等级提供可靠的产品,在早期研发期间更具成本效益。

cGMP制造工艺

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Resources

Time-Saving Dendritic Cell Generation No Medium Change - Less Reagents With HumanKine® GM-CSF and HumanKine IL4

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HumanKine® IL-23 100x More Potent For Induction of Human Th17 Cells


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Effective Polarization of Human Th17 Cells with Biologically Relevant HumanKine® TGFβ1, TGFβ2, and TGFβ3 Expressed in Human Cells

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Efficient Induction of Th17 Cells with HumanKine® TGFβ1


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Native Glycosylation Is Important For Biological Function and Activity of Recombinant Human Proteins

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HumanKine® IL-17 Effective Tool for Autoimmune Disease Research


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Effective Differentiation of Th17 Cells With HumanKine® Cytokines Expressed in Human Cells

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HumanKine® Noggin Human Cell-expressed Glycosylated Disulfide-linked Homodimer

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Mesenchymal Stem Cell

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Wnt Signaling

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Induced Pluripotent Stem Cell

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TGF-beta Signaling

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Haematopoietic Stem Cell

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BMP-2

Independent research demonstrates HEK293 derived BMP-2 is more active and stable than either E.coli or CHO derived BMP-2.

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IL-2

Proteintech's HumanKine recombinant IL-2 is 40x more active than leading competitor product.

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Wnt3A

High purity, high activity Wnt3A, without the high price.


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Product Flyer

HumanKine Cytokines and Growth Factors.



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Product Flyer

cGMP Grade HumanKine Cytokines and Growth Factors.


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Recent Publications

Front. Bioeng. Biotechnol.

Mechano-Hypoxia Conditioning of Engineered Human Meniscus

Alexander R A Szojka