Coronavirus (COVID-19) products
Coronavirus (COVID-19) research, products and information
Coronavirus (COVID-19) Background
Novel Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The name coronavirus refers to its halo-like appearance; visually similar to a 'solar corona' around the virus particles when viewed under a microscope.
Cellular entry of COVID-19
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Image on the left adapted from the Journal of Virology paper by Heurich et al. PMID: 24227843 Click image to enlarge |
Patient-derived anti-SARS-CoV-2 recombinant antibodies
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| Catalog number | Product name | Applications | Species reactivity | Publications |
| 60099-1-Ig | Human IgA Monoclonal Antibody | WB, IHC, IF, ELISA | Human | 1 |
| 66484-1-Ig | Human IgM Monoclonal Antibody | WB, IHC, IF | Human | |
| CL488-66484 | CL488-human IgM Monoclonal Antibody | WB, IHC, IF | Human | 1 |
| CL594-66484 | CL594-human IgM Monoclonal Antibody | WB, IHC, IF | Human | |
| 11016-1-AP | Human IgM Polyclonal Antibody | WB, IHC | Human | |
| 10284-1-AP | Rabbit Anti-Human IgG | WB, IHC | Human | 3 |
| HRP-66484 | HRP-Conjugated Human IgM Antibody | WB, ELISA | Human |
| Catalog number | Product name | Applications | Species reactivity | Publications |
| 14955-1-AP | Human OAS1 Polyclonal Antibody | IF, IHC, WB, | Human, Mouse, Rat | 5 |
| 19279-1-AP | Human OAS2 Polyclonal Antibody | IF, IHC, IP, WB, | Human, Mouse | 7 |
| 21915-1-AP | Human OAS3 Polyclonal Antibody | WB. IHC, IF | Human | 1 |
| Catalog number | Product name | Applications | Species reactivity | Publications |
| 12216-1-AP | Human Cathepsin B Polyclonal Antibody | FC, IF, IHC, WB, | Human, Mouse | 15 |
| 14437-1-AP | Human TMPRSS2 Polyclonal Antibody | IHC, WB, | Human, Mouse, Rat | 7 |
| Catalog number | Product name | Applications | Species reactivity | Publications |
| 13744-1-AP | Human TRIM22 Polyclonal Antibody | IHC, WB, | Human, Mouse | 2 |
| 10326-1-AP | Human TRIM32 Polyclonal Antibody | IF, IHC, WB, | Human, Mouse, Rat | 2 |
| 10851-1-AP | Human TRIM11 Polyclonal Antibody | IHC, WB, | Human | 6 |
| 11476-1-AP | Human TRIM5 Polyclonal Antibody | WB | Human, Mouse | |
| 67492-1-Ig | Human TRIM5 Monoclonal Antibody | WB | Human | |
| 13623-1-AP | Human TRIM15 Polyclonal Antibody | IF, WB | Human, Mouse | 3 |
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SARS-CoV-2 viral entry and impairment of sense of smell - Research published in ACS Chemical Neuroscience by Bilinska et al. Summary provided by Rafal Butowt, PhD, Department of Molecular Cell Genetics, L. Rydygier Collegium Medicum, Nicolaus Copernicus University (Poland), corresponding author. In the current coronavirus pandemic, a relatively large number of patients have a total loss (anosmia) or deficit of smell (hyposmia), but the mechanism is unknown. Using a mouse model, we showed that cells in the olfactory epithelium lying within the nasal cavity express host receptors that enable the SARS-CoV-2 virus to enter and infect selected cells. We identified these cells as sustentacular cells which are located near olfactory receptor neuronal dendrites containing odorant receptors. These cells are metabolically coupled with olfactory receptor neurons, participating in detoxification, odorant-desensitization and as an energy supplier to the olfactory neurons. Thus, SARS-CoV-2 infection of sustentacular cells could explain the olfactory deficient phenotype in COVID-19 patients. We also show that some proteins important for SARS-CoV-2 entry are at higher levels in older mice olfactory epithelium than in younger mice. It is speculated that sustentacular cells in the olfactory epithelium may contain more SARS-CoV-2 viral particle than cells in the oral cavity, making it easier to detect people that are infected with the virus. Butowt and colleagues used Proteintech’s ACE2 antibody (21115-1-AP) to detect expression of the target in olfactory tissue throughout the study. Proteintech’s HSP25 antibody (18284-1-AP) was used to mark sustentacular cells of the olfactory epithelium. |
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Pathogenesis of SARS-CoV-2 in human respiratory tract and conjunctiva. Research published in The Lancet Respiratory Medicine featuring Proteintech’s CC10/Uteroglobin (10490-1-AP). |
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MTHFD1 Antibody (10794-1-AP) - Anderson et al. |
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No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes TMPRSS2 Antibody (14437-1-AP) – Baratchian et al. |
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LY6E Restricts the Entry of Human Coronaviruses, including the currently pandemic 4 SARS-CoV-2 LY6E Antibody (22144-1-AP) - Zhao et al |
Supply Chain Notice
Proteintech is committed to ensuring your research continues during the COVID-19 situation. We understand much of your research is extremely important to the health of the community. As an original manufacturer for its entire catalog of antibodies and proteins, we are here to support you.
Proteintech has five sites globally with full stock inventory available for next day delivery. For this reason, we do not anticipate any issues with our supply chain and orders received will continue to be processed as normal until further notice.
Moreover, we hope you and your family, friends and colleagues remain safe and well. We will keep a close monitoring of the situation and will update our efforts accordingly.
If you have any questions or concerns, please contact us.
Downloads
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COVID-19 and Viral Infection Products Catalog Find all products related to covid-19 and viral infection in a 16 page PDF catalog.
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COVID-19 Overview 2 page PDF covering the SARS-COV-2 cellular entry mechanism with ACE2 and TMPRSS2 product focuses.
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SARS-COV-2 Cellular Entry Diagram PDF diagram of the SARS-COV-2 cellular entry mechanism.