验证数据展示
经过测试的应用
| Positive WB detected in | Jurkat cells, K-562 cell, mouse liver tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
13083-1-AP targets IFNAR1 in WB, IF, IP, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, ELISA Application Description |
| 文献引用应用 | WB, IF, IP |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human, pig |
| 免疫原 | IFNAR1 fusion protein Ag3739 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | interferon (alpha, beta and omega) receptor 1 |
| 别名 | AVP, CRF2 1, IFN alpha REC, IFN alpha/beta receptor 1, IFN R 1, IFNAR, IFNAR1, IFNBR, IFRC, Type I interferon receptor 1 |
| 计算分子量 | 557 aa, 64 kDa |
| 观测分子量 | 64 kDa |
| GenBank蛋白编号 | BC021825 |
| 基因名称 | IFNAR1 |
| Gene ID (NCBI) | 3454 |
| RRID | AB_2122626 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P17181 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Interferon alpha and beta receptor subunit 1 (IFNAR1) is a type I membrane protein that associates with IFNAR2 to form the receptor for type I interferons, including interferons-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2, and then increase transcription of the IFN-induced genes whose products exert antiviral, immunomodulatory, and antiproliferative effects.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for IFNAR1 antibody 13083-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
EMBO Rep Degradation of WTAP blocks antiviral responses by reducing the m 6 A levels of IRF3 and IFNAR1 mRNA | ||
Elife The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress.
| ||
J Virol African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway | ||
Cell Rep TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I-dependent interferon response. |