NeutraControl IL-10 Monoclonal antibody

NeutraControl IL-10 Monoclonal Antibody for ELISA, Non-Neutralization
Cat No. 69518-1-Ig

产品说明书

CloneNo. 6C6E6

宿主/亚型

Mouse / IgG1

种属反应性

Human and More (1)

应用

ELISA, Non-Neutralization and More (1)

CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, TGIF

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


发表文章中的应用

WBSee 1 publications below

产品信息

69518-1-Ig targets IL-10 in WB, ELISA, Non-Neutralization applications and shows reactivity with Human samples.

经测试应用 ELISA, Non-Neutralization Application Description
文献引用应用WB
经测试反应性 Human
文献引用反应性mouse
免疫原 human Humankine IL-10 protein HZ-1145 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 interleukin 10
别名 CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, TGIF
基因名称 IL-10
Gene ID (NCBI) 3586
RRIDAB_2918852
偶联类型 Unconjugated
形式 Lyophilized Powder
纯化方式Protein G purification
储存缓冲液 Sterile PBS , pH 7.4
内毒素<0.1 EU/μg
复溶This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
稳定性与储存Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

背景介绍

The human IL10 gene is 4.7 kb in size and is located on the long arm of chromosome 1. It contains five exons. Biologically functional IL-10 exists in the form of a 36 kDa homodimer composed of two non-covalently bonded mono-mers each with 160 amino acids length. IL-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

This antibody is a neutralizing control antibody for IL-10, the immunogen is the same as Neutrakine 69018-1-Ig but could not neutralize human IL-10.

发表文章

SpeciesApplicationTitle
mouseWB

Cell Commun Signal

Schistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D

Authors - Yao Liao
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