验证数据展示
| Neutralization | BALB/3T3 |
发表文章中的应用
| ELISA | See 1 publications below |
产品信息
69020-1-Ig targets NeutraKine® PDGF-BB in ELISA, Neutralization, Cell treatment applications and shows reactivity with Human samples.
| 经测试应用 | ELISA, Neutralization Application Description |
| 文献引用应用 | ELISA, Cell treatment |
| 经测试反应性 | Human |
| 文献引用反应性 | human |
| 免疫原 | human Humankine PDGF-BB protein HZ-1308 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) |
| 别名 | Becaplermin, c sis, FLJ12858, NeutraKine® PDGF-BB, PDGF 2, PDGF subunit B, PDGF2, PDGFB, PDGFbb, PDGF-BB, Proto oncogene c Sis, SIS, SSV |
| 基因名称 | PDGFB |
| Gene ID (NCBI) | 5155 |
| RRID | AB_2918840 |
| 偶联类型 | Unconjugated |
| 形式 | Lyophilized Powder |
| 纯化方式 | Protein A purification |
| 储存缓冲液 | Sterile PBS. |
| 内毒素 | <0.1 EU/μg |
| 复溶 | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| 稳定性与储存 | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
背景介绍
Platelet-derived growth factor (PDGF) belongs to the family of growth factors consisting of four secreted extracellular ligands including PDGF-A, -B, -C and -D. These isoforms, PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD, act via two receptor tyrosine kinases, PDGF receptors alpha and beta. PDGF isoforms stimulate growth, survival and motility of mesenchymal cells and certain other cell type. They have important functions during embryonal development and in the control of tissue homeostasis in the adult. PDGF-BB is one of the most recently studied isoforms and it plays an important role in skeletal development. PDGF-BB stimulates cell-mediated collagen gel contraction. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors.
This antibody can be used to neutralize the bioactivity of PDGF-BB.
发表文章
| Species | Application | Title |
|---|---|---|
Free Radic Biol Med IRF1/ZNF350/GPX4-mediated ferroptosis of renal tubular epithelial cells promote chronic renal allograft interstitial fibrosis | ||
Metabolism Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway |