NeutraKine® IL-10 Monoclonal antibody

NeutraKine® IL-10 Monoclonal Antibody for IHC, ELISA, Neutralization
Cat No. 69018-1-Ig

产品说明书

CloneNo. 1E4F5

宿主/亚型

Mouse / IgG1

种属反应性

Human and More (2)

应用

IHC, ELISA, Neutralization and More (1)

CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, NeutraKine® IL-10, TGIF

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


Neutralization

产品信息

69018-1-Ig targets NeutraKine® IL-10 in IHC, IF, Neutralization, ELISA applications and shows reactivity with Human samples.

经测试应用 IHC, ELISA, Neutralization Application Description
文献引用应用IHC, IF, Neutralization
经测试反应性 Human
文献引用反应性human, mouse
免疫原 human Humankine IL-10 protein HZ-1145 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 interleukin 10
别名 CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, NeutraKine® IL-10, TGIF
基因名称 IL-10
Gene ID (NCBI) 3586
RRIDAB_2918838
偶联类型 Unconjugated
形式 Lyophilized Powder
纯化方式Protein G purification
储存缓冲液 Sterile PBS , pH 7.4
内毒素<0.1 EU/μg
复溶This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
稳定性与储存Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

背景介绍

Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

This antibody can be used to neutralize the bioactivity of IL-10.

实验方案

Product Specific Protocols
IHC protocol for NeutraKine® IL-10 antibody 69018-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouseIHC

Front Cell Dev Biol

Melatonin Promotes the Therapeutic Effect of Mesenchymal Stem Cells on Type 2 Diabetes Mellitus by Regulating TGF-β Pathway.

Authors - Balun Li
mouseIHC

Int J Biol Sci

NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer.

Authors - Rui Bai
humanNeutralization,IF

Gut Microbes

Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics

Authors - Li-Wei Xie
mouse

Cell Metab

Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages

Authors - Xiaoli Wei
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