NeutraKine® IL-10 Monoclonal antibody, PBS Only (Capture)

NeutraKine® IL-10 Monoclonal Antibody for IHC, Neutralization, ELISA, Sandwich ELISA, Indirect ELISA
Cat No. 69018-1-PBS

产品说明书

CloneNo. 1E4F5

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

IHC, Neutralization, ELISA, Sandwich ELISA, Indirect ELISA

IL-10,IL10, IL-10, IL10, IL 10, CSIF

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

69018-1-PBS targets NeutraKine® IL-10 as part of a matched antibody pair:

MP50035-1: 69018-1-PBS capture and 69018-2-PBS detection (validated in Sandwich ELISA)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 IHC, Neutralization, ELISA, Sandwich ELISA, Indirect ELISA Application Description
经测试反应性 human
免疫原 human Humankine IL-10 protein HZ-1145 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 interleukin 10
别名 IL-10,IL10, IL-10, IL10, IL 10, CSIF
基因名称 IL-10
Gene ID (NCBI) 3586
RRIDAB_2918838
偶联类型 Unconjugated
形式 Lyophilized Powder
纯化方式Protein A purification
储存缓冲液 PBS only , pH 7.3
内毒素<0.1 EU/μg
复溶This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
稳定性与储存Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

背景介绍

Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

This antibody can be used to neutralize the bioactivity of IL-10.

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