验证数据展示
Neutralization |
产品信息
69011-1-Ig targets NeutraKine® BMP-7 in FC (Intra), Neutralization, ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | FC (Intra), Neutralization, ELISA Application Description |
经测试反应性 | human, mouse |
免疫原 | human Humankine BMP-7 protein HZ-1229 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | bone morphogenetic protein 7 |
别名 | BMP7, Eptotermin alfa, Bone morphogenetic protein 7, BMP-7, BMP 7 |
基因名称 | BMP7 |
Gene ID (NCBI) | 655 |
RRID | AB_2882929 |
偶联类型 | Unconjugated |
形式 | Lyophilized Powder |
纯化方式 | Protein G purification |
储存缓冲液 | Sterile PBS , pH 7.4 |
内毒素 | <0.1 EU/μg |
复溶 | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
稳定性与储存 | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
背景介绍
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
BMP7, also known as osteogenic protein-1 or OP-1, plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in cancers, including breast, prostate, and colon cancers, in which it is implicated in regulating cancer cell proliferation (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients was significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).
This antibody can be used to neutralize the bioactivity of BMP-7.