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NeutraKine® IFN Alpha 2A Monoclonal antibody

NeutraKine® IFN Alpha 2A Monoclonal Antibody for ELISA, Neutralization

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

ELISA, Neutralization

Conjugate

Unconjugated

CloneNo.

2H8G1

Cat no : 69008-1-Ig

Print datasheet

Synonyms

IFN alpha 2, IFNA, IFNA2, IFN-alpha 2, INFA2, Interferon alpha 2, Interferon alpha A, interferon, alpha 2, LeIF A, NeutraKine® IFN Alpha 2A

验证数据展示

  • Neutralization experiment of NeutraKine® IFN Alpha 2A using 69008-1-Ig

    Neutralization experiment of NeutraKine® IFN Alpha 2A using 69008-1-Ig

    Recombinant human IFN alpha 2A (Cat.NO. HZ-1066) inhibits the growth of TF-1 cell line (human erythroleukemic cell line) in a dose-dependent manner (blue curve, refer to bottom X-left Y). The activity of human IFN alpha 2A (100 ng/mL HZ-1066) is neutralized by mouse anti-human IFN alpha 2A monoclonal antibody 69008-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 300-500 ng/mL.

Neutralization

产品信息

69008-1-Ig targets NeutraKine® IFN Alpha 2A in ELISA, Neutralization applications and shows reactivity with Human samples.

Tested Applications ELISA, Neutralization Application Description
Tested Reactivity Human
Immunogen human Humankine IFN Alpha 2A protein HZ-1066 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name interferon, alpha 2
Synonyms IFN alpha 2, IFNA, IFNA2, IFN-alpha 2, INFA2, Interferon alpha 2, Interferon alpha A, interferon, alpha 2, LeIF A, NeutraKine® IFN Alpha 2A
Gene Symbol IFN alpha2
Gene ID (NCBI) 3440
RRIDAB_2882926
Conjugate Unconjugated
Form Lyophilized Powder
Purification MethodProtein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

背景介绍

Interferon alpha 2 is a type 1 interferon. Interferon alpha 2 is secreted by virus-infected cells and inhibits other cells from further infection. Recombinant human interferon alpha 2 has been approved for therapeutic application in a range of human oncological and viral diseases. Three Interferon alpha 2 subvariants (2A, 2B, 2C) differ by only one or two amino acids at positions 23 and/or 34 of the mature protein (PMID: 25982860; 10672347; 1694761).

This antibody can be used to neutralize the bioactivity of Interferon alpha 2.