NeutraKine® TNF-alpha Monoclonal antibody

NeutraKine® TNF-alpha Monoclonal Antibody for Neutralization, ELISA
Cat No. 69002-1-Ig

产品说明书

CloneNo. 11H8A5

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse

应用

Neutralization, ELISA

NeutraKine® TNF Alpha, TNF, TNF alpha, TNF-a, Intracellular domain 2

缓冲液配方:  Sterile PBS.
Sterile PBS.
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy TNF Ready-To-Use IHC Kit. TNF primary antibody included.
Planning an IF experiment? We recommend our CoraLite® Plus 488 and CoraLite® Plus 647 conjugated versions of this antibody.
Neutralization

产品信息

69002-1-Ig targets NeutraKine® TNF-alpha in Neutralization, ELISA applications and shows reactivity with human, mouse samples.

经测试应用 Neutralization, ELISA Application Description
文献引用应用Neutralization
经测试反应性 human, mouse
免疫原 human Humankine TNF-alpha protein HZ-1014 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 tumor necrosis factor (TNF superfamily, member 2)
别名 NeutraKine® TNF Alpha, TNF, TNF alpha, TNF-a, Intracellular domain 2
基因名称 TNF-alpha
Gene ID (NCBI) 7124
ENSEMBL Gene IDENSG00000232810
RRIDAB_2882920
偶联类型 Unconjugated
形式 Lyophilized Powder
纯化方式Protein A purification
储存缓冲液 Sterile PBS.
内毒素<0.1 EU/μg
复溶This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
稳定性与储存Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

背景介绍

TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, INS resistance, and cancer.

This antibody can be used to neutralize the bioactivity of TNF alpha.

发表文章

SpeciesApplicationTitle
Neutralization

Cell Mol Gastroenterol Hepatol

Fatty Acid Oxidation Promotes Apoptotic Resistance and Proinflammatory Phenotype of CD4+ Tissue-resident Memory T cells in Crohn's Disease

Authors - Guanzhan Liang

Int J Mol Sci

Cancerous Conditions Accelerate the Aging of Skeletal Muscle via Mitochondrial DNA Damage

Authors - Yi Luo
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