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NeutraKine® Cystatin C Monoclonal antibody

NeutraKine® Cystatin C Monoclonal Antibody for ELISA, Neutralization

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

ELISA, Neutralization

Conjugate

Unconjugated

CloneNo.

1H1B4

Cat no : 69017-1-Ig

Print datasheet

Synonyms

ARMD11, CST3, Cystatin 3, cystatin C, Gamma trace, NeutraKine® Cystatin C, Post gamma globulin

验证数据展示

  • Neutralization experiment of NeutraKine® Cystatin C using 69017-1-Ig

    Neutralization experiment of NeutraKine® Cystatin C using 69017-1-Ig

    Recombinant human Cystatin C (Cat.NO. HZ-1211) inhibits Papain protease (5 μg/mL) activity (by colorimetric assay using L-BAPA as substrate) in a dose-dependent manner (blue curve, refer to bottom X-left Y). The activity of human Cystatin C (0.4 μg/mL HZ-1211) is neutralized by mouse anti-human Cystatin C monoclonal antibody 69017-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is around 0.5mg/mL.

Neutralization

产品信息

69017-1-Ig targets NeutraKine® Cystatin C in ELISA, Neutralization applications and shows reactivity with Human samples.

Tested Applications ELISA, Neutralization Application Description
Tested Reactivity Human
Immunogen human Humankine Cystatin C protein HZ-1211 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name cystatin C
Synonyms ARMD11, CST3, Cystatin 3, cystatin C, Gamma trace, NeutraKine® Cystatin C, Post gamma globulin
Gene Symbol Cystatin C
Gene ID (NCBI) 1471
RRIDAB_2918837
Conjugate Unconjugated
Form Lyophilized Powder
Purification MethodProtein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

背景介绍

Cystatin C is a 13-kDa inhibitor of cysteine proteinases which is secreted by all cell types and is completely cleared from the organism through glomerular filtration, shown to be an early and sensitive biomarker of renal dysfunction. It is also used as an emerging biomarker in cardiovascular disease. Cystatin C is involved in a variety of inflammatory reactions. The concentration of serum cystatin C has also been shown to be unaltered in certain inflammatory conditions or other disorders of metabolism. The plasma level of serum cystatin C can be expressed as its level of generation from cells and diet and its subsequent elimination through the gut, liver, and kidneys.

This antibody can be used to neutralize the bioactivity of Cystatin C.