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DNMT1 antibody (mAb) (Clone 2C1)

Host / Isotype

Rat / IgG2b

Reactivity

Human

Applications

ChIP, IP, WB

CloneNo.

2C1

Cat No : 61467,61468 61467

Synonyms

DNMT1, DNMT 1, DNA methyltransferase 1, DNA (Cytosine-5-)-Methyltransferase 1, DNA MTase HsaI, MCMT, CXXC9, HSN1E, DNMT, DNA (Cytosine-5)-Methyltransferase 1, AIM, M.HsaI, CXXC-Type Zinc Finger Protein 9, Dnmt1, DNA Methyltransferase HsaI, M.HsaI, DNA methylation, antibody, antibodies, monoclonal, chromatin immunoprecipitation, chip, immunoprecipitation, ip, western blotting, wb, stem cell, stem cells, sample

验证数据展示

产品信息

Tested Applications ChIP, IP, WB

This antibody is also available as an AbFlex engineered recombinant antibody. For details on the corresponding AbFlex Recombinant Antibody, see Catalog No. 91175.
Tested Reactivity Human
Host / Isotype Rat / IgG2b
Class Monoclonal
Type Antibody
Immunogen This antibody was raised against a full-length recombinant protein corresponding to human DNMT1.
Full Name DNMT1 antibody (mAb) (Clone 2C1)
Synonyms DNMT1, DNMT 1, DNA methyltransferase 1, DNA (Cytosine-5-)-Methyltransferase 1, DNA MTase HsaI, MCMT, CXXC9, HSN1E, DNMT, DNA (Cytosine-5)-Methyltransferase 1, AIM, M.HsaI, CXXC-Type Zinc Finger Protein 9, Dnmt1, DNA Methyltransferase HsaI, M.HsaI, DNA methylation, antibody, antibodies, monoclonal, chromatin immunoprecipitation, chip, immunoprecipitation, ip, western blotting, wb, stem cell, stem cells, sample
Molecular weight 190 kDa
GenBank accession numberNP_001124295
RRIDAB_2614954
Purification Method Protein G Chromatography
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

背景介绍

DNMT1 (DNA (cytosine-5)-methyltransferase) proteins are involved in DNA methylation in which a methyl group is added to a cytosine residue on DNA, commonly at the C5 position of a CpG dinucleotide. Three families of DNMTs have been identified: DNMT1, DNMT2, and DNMT3 (comprised of DNMT3A and DNMT3B). DNMT1 is the most abundant DNMT in somatic cells and shows a preference for methylating hemi-methylated DNA. It is considered to be a maintenance DNA methyltransferase that is important in the maintenance of specific patterns of methylation throughout cellular divisions. Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as embryonic development, genetic imprinting, X chromosome inactivation and the control of gene expression. DNA methylation is generally associated with transcriptional repression.