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HDAC11 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human, Mouse, Rat

Applications

WB

Cat No : 39208 39208

Synonyms

HDAC, HDAC11, HDAC-11, HDAC 11, pAb, polyclonal, Histone deacetylase 11, antibody, antibodies

验证数据展示

  • HDAC11 pAb tested by Western blot. Detection of HDAC11 by Western blot. The analysis was performed using HDAC11 pAb at a dilution of 2 ug/ml and brain whole-cell extracts from human (lane 1), mouse (lane 2) or rat origin.

    HDAC11 pAb tested by Western blot. Detection of HDAC11 by Western blot. The analysis was performed using HDAC11 pAb at a dilution of 2 ug/ml and brain whole-cell extracts from human (lane 1), mouse (lane 2) or rat origin.

产品信息

Tested Applications WB

Applications Validated by Active Motif: WB: 1 - 3 ug/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all blocking solutions may also reduce background. Individual optimization may be required.
Tested Reactivity Human, Mouse, Rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This HDAC11 antibody was raised against a peptide corresponding to amino acid residues 238-251 of human HDAC11.
Full Name HDAC11 antibody (pAb)
Synonyms HDAC, HDAC11, HDAC-11, HDAC 11, pAb, polyclonal, Histone deacetylase 11, antibody, antibodies
Molecular weight 36 kDa
GenBank accession numberNP_001129513
RRIDAB_2614938
Purification Method Affinity Purified
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

背景介绍

HDAC11 (Histone Deacetylase 11) is a member of the class IV mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-e-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the e-amino group of a lysine residue. In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11). In humans, expression of HDAC11 is limited to only a few organs, including brain, heart, muscle and kidney, suggesting an important role of HDAC11 in those tissues.