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PRMT2 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

ICC, IF, WB

Cat No : 61491,61492 61491

Synonyms

PRMT2, Protein Arginine Methyltransferase 2, PRMT2 Alpha, HRMT1L1, PRMT2 Beta, HMT1 (HnRNP Methyltransferase, S. Cerevisiae)-Like 1, PRMT2 Gamma2, Histone-Arginine N-Methyltransferase PRMT2, Protein Arginine N-Methyltransferase 2, HMT1 HnRNP Methyltransferase-Like 1 (S. Cerevisiae), HMT1 HnRNP Methyltransferase-Like 1, HMT1, methyltransferase, methyl, STAT3, Histone H4, antibody, polyclonal, pAb, western blot, wb, sample

验证数据展示

  • PRMT2 antibody (pAb) tested by Immunofluorescence. Formaldehyde fixed HeLa cells stained with PRMT2 antibody at a 1:2,000 dilution.

    PRMT2 antibody (pAb) tested by Immunofluorescence. Formaldehyde fixed HeLa cells stained with PRMT2 antibody at a 1:2,000 dilution.

  • PRMT2 antibody (pAb) tested by Western blot. Nuclear extract of U373 MG cells (20 ug) probed with PRMT2 antibody (pAb) at a dilution of 1:1,000.

    PRMT2 antibody (pAb) tested by Western blot. Nuclear extract of U373 MG cells (20 ug) probed with PRMT2 antibody (pAb) at a dilution of 1:1,000.

产品信息

Tested Applications ICC, IF, WB

Applications Validated by Active Motif: ICC/IF: 1:2,000 dilution WB: 1:500 - 1:2,500 dilution
Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This antibody was raised against a peptide within the N-terminal region of human PRMT2.
Full Name PRMT2 antibody (pAb)
Synonyms PRMT2, Protein Arginine Methyltransferase 2, PRMT2 Alpha, HRMT1L1, PRMT2 Beta, HMT1 (HnRNP Methyltransferase, S. Cerevisiae)-Like 1, PRMT2 Gamma2, Histone-Arginine N-Methyltransferase PRMT2, Protein Arginine N-Methyltransferase 2, HMT1 HnRNP Methyltransferase-Like 1 (S. Cerevisiae), HMT1 HnRNP Methyltransferase-Like 1, HMT1, methyltransferase, methyl, STAT3, Histone H4, antibody, polyclonal, pAb, western blot, wb, sample
Molecular weight 55 kDa
GenBank accession numberNP_996845
RRIDAB_2793656
Purification Method Affinity Purified
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

背景介绍

PRMT2 (Protein Arginine Methyltransferase 2) is a member of the protein arginine N-methyltransferase (PRMT) family that is capable of monomethylating and asymmetrically dimethylating arginine residues. PRMT2 is an arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.