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Sox2 antibody (pAb)

Host / Isotype

Rabbit / Serum

Reactivity

Mouse

Applications

ICC, IF, IHC, WB

Cat No : 39823,39824 39823

Synonyms

Sox2, SRY related HMG BOX gene 2, sox, sox 2, sox-2, embryogenesis, embryonic stem cell pluripotency, es cell, esc, Induced Pluripotency, microphthalmia, sample, stem cell, stem cells, chiphsabs

验证数据展示

  • Sox2 antibody (pAb) tested by Western blot. HeLa cell extract expressing mouse Sox2 (50 ug per lane) probed with Sox2 antibody at a dilution of 1:5,000.

    Sox2 antibody (pAb) tested by Western blot. HeLa cell extract expressing mouse Sox2 (50 ug per lane) probed with Sox2 antibody at a dilution of 1:5,000.

产品信息

Tested Applications ICC, IF, IHC, WB

Applications Validated by Active Motif: WB: 1:2,000 - 1:10,000 dilution
Tested Reactivity Mouse
Host / Isotype Rabbit / Serum
Class Polyclonal
Type Antibody
Immunogen This Sox2 antibody was raised against a peptide corresponding to amino acids amino acids 111-140 mouse Sox2.
Full Name Sox2 antibody (pAb)
Synonyms Sox2, SRY related HMG BOX gene 2, sox, sox 2, sox-2, embryogenesis, embryonic stem cell pluripotency, es cell, esc, Induced Pluripotency, microphthalmia, sample, stem cell, stem cells, chiphsabs
Molecular weight 35 kDa
GenBank accession numberNP_035573
RRIDAB_2793356
Purification Method None
Buffer Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

背景介绍

Sox2 (SRY related HMG BOX gene 2) is a DNA binding transcription factor and a member of the SOX family of proteins. SOX proteins have an HMG box that binds DNA. Sox2 forms a complex with Oct-4 and controls the expression of a number of genes involved in embryonic. Sox2 is critical for early embryogenesis and for embryonic stem cell pluripotency and thus can serve as a stem cell marker. Overexpression of Sox2 (along with Oct-4, KLF4 and c-Myc) can transform mouse fibroblasts into a state resembling embryonic stem cells (ES cells), referred to as Induced Pluripotency. Defects in Sox2 are the cause of microphthalmia syndromic type 3.