TAZ / WWTR1 antibody (pAb)
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
WB
Cat No : 61265,61266 61265
Synonyms
验证数据展示
产品信息
| Tested Applications |
WB
Applications Validated by Active Motif: WB: 1:500 - 1:1,000 dilution |
| Tested Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | TAZ / WWTR1 antibody was raised against a peptide corresponding to the C-terminal region of human TAZ / WWTR1. |
| Full Name | TAZ / WWTR1 antibody (pAb) |
| Synonyms | TAZ / WWTR1, Transcriptional coactivator with PDZ-binding motif, WW domain-containing transcription regulator protein 1, DKFZp586I1419, FLJ27004, FLJ45718, transcription, antibody, pAb, polyclonal, rabbit, sample, stem cell, stem cells, hippo, yap1, yap, pax8, nkx2-1, ttft, smad |
| Molecular weight | 55 kDa |
| GenBank accession number | NP_056287 | RRID | AB_2614991 | Purification Method | Affinity Purified |
| Buffer | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
背景介绍
The TAZ / WWTR1 (Transcriptional coactivator with PDZ-binding motif, WW domain-containing transcription regulator protein 1) gene encodes a protein that is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.