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验证数据展示

  • IHC staining of mouse cerebellum using 21766-1-AP

    IHC staining of mouse cerebellum using 21766-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 21766-1-AP (GABRA6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IHC staining of mouse cerebellum using 21766-1-AP

    IHC staining of mouse cerebellum using 21766-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 21766-1-AP (GABRA6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IF Staining of mouse cerebellum using 21766-1-AP

    IF Staining of mouse cerebellum using 21766-1-AP

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse cerebellum tissue using GABRA6 antibody (21766-1-AP) at dilution of 1:500 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

GABRA6 Polyclonal antibody

GABRA6 Polyclonal Antibody for IHC, IF-P, ELISA
Cat No. 21766-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, IF-P, ELISA

别名

GABA A receptor alpha 6, GABA(A) receptor subunit alpha-6, GABAA receptor alpha 6, GABAAR subunit alpha-6, GABRA 6

缓冲液配方:  PBS, Azide, Glycerol
PBS, Azide, Glycerol
偶联物:  Unconjugated
Unconjugated
规格价格库存

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经过测试的应用

Positive IHC detected inmouse cerebellum tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF-P detected inmouse cerebellum tissue

推荐稀释比

应用推荐稀释比
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)-PIF-P : 1:250-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

21766-1-AP targets GABRA6 in IHC, IF-P, ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, IF-P, ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag16375

Product name: Recombinant human GABRA6 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 329-424 aa of BC096241

Sequence: NLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRIL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 gamma-aminobutyric acid (GABA) A receptor, alpha 6
别名 GABA A receptor alpha 6, GABA(A) receptor subunit alpha-6, GABAA receptor alpha 6, GABAAR subunit alpha-6, GABRA 6
计算分子量 453 aa, 51 kDa
GenBank蛋白编号BC096241
基因名称 GABRA6
Gene ID (NCBI) 2559
RRIDAB_3085671
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ16445
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. GABAA receptors are formed by pentameric assembly of 19 different subunit subtypes (α1-α6, β1-β3, γ1-γ3, δ, ɛ, π, θ and ρ1-ρ3) (PMID: 21930603). The mutation R46W of GABRA6 is associated with the pathogenesis of childhood absence epilepsy (CAE) (PMID: 21930603).

实验方案

Product Specific Protocols
IF protocol for GABRA6 antibody 21766-1-APDownload protocol
IHC protocol for GABRA6 antibody 21766-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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