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  • Featured Product
  • KD/KO Validated

CXCL16 Monoclonal antibody, PBS Only (Detector)

CXCL16 Monoclonal Antibody for WB, Cytometric bead array, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, mouse

Applications

WB, Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H7B3

Cat no : 60123-1-PBS

Print datasheet

Synonyms

Small-inducible cytokine B16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, CXCL 16, C-X-C motif chemokine 16, C X C motif chemokine 16

验证数据展示

  • WB analysis using 60123-1-Ig (same clone as 60123-1-PBS)

    WB analysis using 60123-1-Ig (same clone as 60123-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60123-1-Ig (CXCL16 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60123-1-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP51127-1

    Cytometric bead array standard curve of MP51127-1

    Cytometric bead array standard curve of MP51127-1, CXCL16 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60123-2-PBS. Detection antibody: 60123-1-PBS. Standard:Ag4883. Range: 0.391-100 ng/mL.

产品信息

60123-1-PBS targets CXCL16 as part of a matched antibody pair:

MP51127-1: 60123-2-PBS capture and 60123-1-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Applications WB, Cytometric bead array, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen CXCL16 fusion protein Ag4883 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name chemokine (C-X-C motif) ligand 16
Synonyms Small-inducible cytokine B16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, CXCL 16, C-X-C motif chemokine 16, C X C motif chemokine 16
Calculated Molecular Weight 273 aa, 30 kDa
Observed Molecular Weight 35 kDa, 60 kDa
GenBank Accession NumberBC017588
Gene Symbol CXCL16
Gene ID (NCBI) 58191
RRIDAB_2086188
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ9H2A7
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CXCL16 is a recently discovered cytokine belonging to the CXC chemokine family, which is synthesised in plasmacytoid dendritic cell as a transmembrane molecule. It exists in a transmembrane and soluble form. The transmembrane form of CXCL16 functions as an adhesion molecule for CXCR6-expressing cells, whereas the soluble form of CXCL16 mediates infiltration of circulating cells into sites of injury. CXCL16, has been proposed as an important pathogenic mediator in inflammatory diseases, including rheumatoid arthritis, glomerulonephritis, or prostate cancer. CXCL16 has been implicated in some forms of renal disease such as lupus nephritis and antiglomerular basement membrane nephritis. CXCL16 also plays a pivotal role in the pathogenesis of angiotensin II-induced renal injury and fibrosis through regulation of macrophage and T cell infiltration and bone marrow-derived fibroblast accumulation.