验证数据展示
产品信息
66077-1-PBS targets TELO2 as part of a matched antibody pair:
MP50016-1: 66077-2-PBS capture and 66077-1-PBS detection (validated in Cytometric bead array, Sandwich ELISA)
Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
经测试应用 | WB, IHC, IF/ICC, IP, Cytometric bead array, Sandwich ELISA, Indirect ELISA Application Description |
经测试反应性 | human, rat |
免疫原 | TELO2 fusion protein Ag8834 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | TEL2, telomere maintenance 2, homolog (S. cerevisiae) |
别名 | TEL2, Protein clk-2 homolog, Protein clk 2 homolog, KIAA0683, hCLK2 |
计算分子量 | 837 aa, 92 kDa |
观测分子量 | 92 kDa |
GenBank蛋白编号 | BC017188 |
基因名称 | TELO2 |
Gene ID (NCBI) | 9894 |
RRID | AB_11182835 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | Q9Y4R8 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
TELO2 gene encodes a telomere length regulation protein TEL2 homolog. TELO2 may be involved in telomere length regulation and can form TTT complex with TTI1 and TTI2. TTT complex is required to stabilize protein levels of PIKK family proteins and is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), and ultraviolet (UV). The activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals, can be promoted, stabilized and maintained by TELO2.