Presenilin-1-Specific Recombinant antibody, PBS Only (Capture)

Presenilin-1-Specific Recombinant Antibody for Cytometric bead array, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

240615G10

Cat No : 83618-2-PBS

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Synonyms

PSEN1-Specific, PSEN1, Presenilin-1 CTF12, Presenilin-1 CTF subunit, Presenilin-1



Planning an IHC experiment? We recommend our IHCeasy PSEN1/AD3 Ready-To-Use IHC Kit. PSEN1/AD3 primary antibody included.

产品信息

83618-2-PBS targets Presenilin-1-Specific as part of a matched antibody pair:

MP00597-1: 83618-2-PBS capture and 83618-1-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Applications Cytometric bead array, Indirect ELISA Application Description
Tested Reactivity human
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name presenilin 1
Synonyms PSEN1-Specific, PSEN1, Presenilin-1 CTF12, Presenilin-1 CTF subunit, Presenilin-1
Calculated Molecular Weight 53 kDa
GenBank Accession NumberNM_000021
Gene Symbol PSEN1
Gene ID (NCBI) 5663
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP49768
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome (PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody is specific to isoform1(53 kDa), isoform2(52 kDa), isoform4(21 kDa), isoform7(49 kDa) of this protein.