验证数据展示
经过测试的应用
| Positive IF/ICC detected in | NK-92 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
85021-4-RR targets NKp46/NCR1 in IF/ICC, ELISA applications and shows reactivity with human samples.
| 经测试应用 | IF/ICC, ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 | Recombinant protein 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | natural cytotoxicity triggering receptor 1 |
| 别名 | NCR 1, Natural killer cell p46-related protein, LY94, hNKp46, CD335 |
| 计算分子量 | 34kDa |
| 基因名称 | NCR1 |
| Gene ID (NCBI) | 9437 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | O76036-1 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
NKp46, also known as natural cytotoxicity triggering receptor 1 (NCR1), is a type I transmembrane protein belonging to the immunoglobulin superfamily. NKp46 is a key activating receptor expressed on natural killer (NK) cells. It plays a key role in the innate immune response by recognizing and binding to viral hemagglutinins and other ligands on infected or tumor cells. NKp46 mediates cytotoxicity and cytokine production upon engagement with its ligands, contributing to the elimination of infected or malignant cells. Its expression and function are tightly regulated, and dysregulation of NKp46 has been implicated in various diseases, including viral infections, cancer, and autoimmune disorders. (PMID: 11234016; 29329948; 9730896; 9314561).
实验方案
| Product Specific Protocols | |
|---|---|
| IF protocol for NKp46/NCR1 antibody 85021-4-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |