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Recombinant Human CEACAM-6/CD66c protein (Myc Tag, His Tag)

种属

Human

纯度

>95 %, SDS-PAGE

标签

Myc Tag, His Tag

生物活性

EC50: 12-46 ng/mL

Cat no : Eg0056

Print datasheet

Synonyms

CEACAM6, Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, CEAL, NCA

验证数据展示

  • Purity of Recombinant Human CEACAM-6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CEACAM-6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

  • Immobilized Human CEACAM-6 (Myc tag, His tag) at 2 μg/mL (100 μL/well) can bind Human CEACAM-8 (hFc tag) with a linear range of 12-46 ng/mL.

    Immobilized Human CEACAM-6 (Myc tag, His tag) at 2 μg/mL (100 μL/well) can bind Human CEACAM-8 (hFc tag) with a linear range of 12-46 ng/mL.

产品信息

纯度 >95 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Immobilized Human CEACAM-6 (Myc tag, His tag) at 2 μg/mL (100 μL/well) can bind Human CEACAM-8 (hFc tag) with a linear range of 12-46 ng/mL.
来源 HEK293-derived Human CEACAM-6 protein Lys35 -Gly320 (Accession# P40199) with a Myc tag and a His tag at the C-terminus.
基因ID 4680
蛋白编号 P40199
预测分子量 36.3 kDa
SDS-PAGE 40-70 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), belonging to the immunoglobulin superfamily, is cell-adhesion protein on neutrophils. CEACAM6 is expressed in neutrophils and numerous tumor cell lines. CEACAM6 mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. It plays a role in neutrophil adhesion to cytokine-activated endothelial cells and plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion. CEACAM6 is also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells.

参考文献:

1.Kuroki M, et al. (2001). Journal of leukocyte biology. 70(4): 543-50 
2.Kuijpers TW, et al. (1992). J Cell Biol. 118(2):457-66
3.Blumenthal RD, et al. (2005). Cancer research. 65(19):8809–8817
4.Ordoñez C, et al. (2000). Cancer Res. 60(13):3419-24
5.Duxbury MS, et al. (2004). Oncogene. 23(2):465-73