• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Recombinant Human Interferon alpha/beta receptor 1 protein (Myc Tag, His Tag)

ED50

/

Species

Human

Purity

>95 %, SDS-PAGE

GeneID

3454

Accession

P17181-1

Cat No : Eg0156

Print datasheet

Synonyms

IFNAR1,AVP,CRF2 1,CRF2-1,Cytokine receptor class-I

验证数据展示

  • Purity of Recombinant Human Interferon alpha/beta receptor 1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Interferon alpha/beta receptor 1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Technical Specifications

Purity >95 %, SDS-PAGE
Endotoxin Level <1.0 EU/μg protein, LAL method
Biological Activity 
Testing in progress
Source HEK293-derived Human Interferon alpha/beta receptor 1 protein Lys28-Lys436 (Accession# P17181-1) with a Myc tag and a His tag at the C-terminus.
Predicted Molecular Mass 52.1 kDa
SDS-PAGE 65-90 kDa, reducing (R) conditions
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Interferon alpha and beta receptor subunit 1 (IFNAR1) is a type I membrane protein that associates with IFNAR2 to form the receptor for type I interferons, including interferons-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2, and then increase transcription of the IFN-induced genes whose products exert antiviral, immunomodulatory, and antiproliferative effects.

References:

1. G Uzé, et al. (2007) Curr Top Microbiol Immunol. 316:71-95.
2. Nicole A de Weerd, et al. (2012) Immunol Cell Biol. 90(5):483-91. 
3. Peter E Kima. (2014) Microbes Infect. 16(9):721-6.