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Recombinant Human TREM2 protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0747

Print datasheet

Synonyms

TREM2, TREM 2, TREM-2, Trem2a, Trem2b

验证数据展示

  • Purity of Recombinant Human TREM2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human TREM2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human TREM2 protein His19-Lys174 (Accession# AAH32362.1) with a His tag at the C-terminus.
基因ID 54209
蛋白编号 AAH32362.1
预测分子量 18.2 kDa
SDS-PAGE 22-32 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

TREM2 (triggering receptor expressed on myeloid cells 2) is a cell surface receptor belongs to TREM family that is expressed on osteoclast, dendritic cells, macrophages, nature killers, neutrophils and microglia. TREM2 is localized predominantly in the Golgi complex, but also shuttles to and from the cell surface in endocytic and exocytic vesicles. It associates with DAP12 to initiate the intracellular signalling cascade via an immunoreceptor tyrosine-based activation motif (ITAM) domain and tyrosine-kinases.

参考文献:

1. Guo, Tianshu. et al. (2022). Front Immunol. 13:963373.
2. Ferri, Evelyn. et al. (2021). Frontiers in molecular biosciences. 7:627931.
3. Diaz-Lucena, Daniela. et al. (2021). Acta Neuropathol. 141(6):841-859. 
4. Liu, Wenwu. et al. (2023). Clin Chim Acta. 548:117499.
5. Piccio, Laura. et al. (2016). Acta Neuropathol. 131(6):925-33.
6. Hu, Nan. et al. (2014). J Alzheimers Dis. 38(3):497-501.