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Recombinant Human IL-23R protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0853

Print datasheet

Synonyms

IL23R, IL 23 receptor, IL 23R, IL-23 receptor, IL-23R

验证数据展示

  • Purity of Recombinant Human IL-23R was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human IL-23R was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human IL-23R protein Gly24-Gly355 (Accession# Q5VWK5-1) with a His tag at the C-terminus.
基因ID 149233
蛋白编号 Q5VWK5-1
预测分子量 39.1 kDa
SDS-PAGE 50-70 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Interleukin-23 receptor (IL23R) is a type I cytokine receptor that plays a pivotal role in the immune system, particularly in the maturation and function of T helper 17 (Th17) cells. IL23R, along with IL12Rβ1, forms the receptor complex necessary for IL-23 signaling, which is critical for the production of IL-17 and the activation of pro-inflammatory activities. This receptor is expressed on various immune cells, including T cells, NK cells, dendritic cells, and macrophages. Research has shown that variations in the IL-23R gene can significantly influence susceptibility to several diseases, particularly inflammatory bowel diseases such as ulcerative colitis (UC) and Crohn's disease (CD). In addition to UC, IL-23R has been implicated in other inflammatory conditions, including rheumatoid arthritis and ankylosing spondylitis.

参考文献:

1.Mezghiche I, et al. (2024) Eur J Immunol. 54 (1):e2250348.
2.Peng LL, et al.(2017) Oncotarget. 8 (3):4849-4863. 
3.Hamdy G, et al. (2015) Hum Immunol. 76 (6):417-20.