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Recombinant Human ASGR1 protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0946

Print datasheet

Synonyms

ASGR1, asialoglycoprotein receptor 1, HL-1, ASGP R 1, ASGPR

验证数据展示

  • Purity of Recombinant Human ASGR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human ASGR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human ASGR1 protein Gln62-Leu291 (Accession# P07306-1) with a His tag at the N-terminus.
基因ID 432
蛋白编号 P07306-1
预测分子量 27.2 kDa
SDS-PAGE 32-38 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Asialoglycoprotein receptor (ASGPR), also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor or Ashwell receptor, is a C-type lectin expressed exclusively in hepatic parenchymal cells. ASGPR consists of two subunits, a major subunit (ASGR1, HL-1) and a minor subunit (ASGR2, HL-2), and specifically recognizes terminal β-linked galactose or GlcNAc on circulating glycoproteins or cells. ASGPR plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins that contain terminal galactose or GlcNAc residues.

参考文献:

1.Meier, M. et al. (2000).  J. Mol. Biol. 300:857.
2.Rigopoulou EI. et al. (2012). Autoimmun Rev. 12(2):260-9. 
3.Weigel, P.H. and J.H.N. Yik (2002). Biochim. Biophys. Acta 1572:341.
4.Meier, M. et al. (2000).  J. Mol. Biol. 300:857.