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Recombinant Human IGFBP-1 protein (His Tag)

ED50

/

Species

Human

Purity

>90 %, SDS-PAGE

GeneID

3484

Accession

P08833

Cat No : Eg0951

Print datasheet

Synonyms

AFBP, hIGFBP 1, IBP 1, IBP1, IBP-1, IGF binding protein 1, IGF BP25, IGF-binding protein 1, IGFBP 1, IGFBP1, IGFBP-1, IGFBP25, Insulin-like growth factor-binding protein 1, Placental protein 12, PP12

验证数据展示

  • Purity of Recombinant Human IGFBP-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human IGFBP-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Technical Specifications

Purity >90 %, SDS-PAGE
Endotoxin Level <1.0 EU/μg protein, LAL method
Biological Activity 
/
Source HEK293-derived Human IGFBP-1 protein Ala26-Asn259 (Accession# P08833) with a His tag at the C-terminus.
Predicted Molecular Mass 26.1 kDa
SDS-PAGE 30-40 kDa, reducing (R) conditions
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

IGFBP-1 (Insulin-like growth factor binding protein-1) belongs to the insulin-like growth factor (IGF) system, which plays an indispensable role in normal growth and development, and in the pathophysiology of various tumors. IGFBP-1 has been shown to be associated with the risk of various tumors, and has a vital function in regulating tumor behaviors such as proliferation, migration, invasion and adhesion through different molecular mechanisms. In addition, As a secreted protein, IGFBP-1 is the most predominant IGFBP in amniotic fluid and expressed steadily and normally in the liver, endometrium and placenta among them. But insulin that can inhibit IGFBP-1 expression through the insulin receptor and growth hormone can regulate IGFBP-1 expression.

References:

1. Yi-Wei Lin. et al. ( 2021). Am J Transl Res. 13(3):813-832.
2. Linn Fagerberg. et al. (2014).  Mol Cell Proteomics. 13(2):397-406.
3.T G Unterman. et al. (1991). Endocrinology.128(6):2693-2701.