Recombinant Rat ICAM-1/CD54 protein (His Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
纯度 | >90 %, SDS-PAGE |
内毒素 | <0.1 EU/μg protein, LAL method |
生物活性 | Not tested |
来源 | HEK293-derived Rat ICAM-1 protein Gln28-Thr493 (Accession# Q00238) with a His tag at the C-terminus. |
基因ID | 25464 |
蛋白编号 | Q00238 |
预测分子量 | 52.2 kDa |
SDS-PAGE | 65-85 kDa, reducing (R) conditions |
组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
ICAM-1 (CD54) is a transmembrane glycoprotein of the immunoglobulin superfamily and is critical for the firm attachment and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is expressed by several cell types, typically on endothelial cells and cells of the immune system, and its expression can be up-regulated by various stimuli, including TNF-α, INF-γ, IL-1 and thrombin. It is a ligand for LFA-1 and Mac-1, serves as a receptor for rhinovirus, and is one of several receptors used by Plasmodium falciparum.
参考文献:
1. M L Dustin, et al. (1986) J Immunol. 137(1):245-54. 2. C W Smith, et al. (1989) J Clin Invest. 83(6):2008-17. 3. D E Staunton, et al. (1989) Cell. 56(5):849-53. 4. A R Berendt, et al. (1989) Nature. 341(6237):57-9. 5. G Kaplanski, et al. (1998) Blood. 92(4):1259-67. 6. Narimasa Miho, et al. (2005) Cardiovasc Res. 68(2):289-98. 7. Charlotte Lawson, et al. (2009) Pharmacol Rep. 61(1):22-32.