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Recombinant Human SOD1 protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

N-His

生物活性

未测试

Cat no : Eg1043

Print datasheet

Synonyms

SOD1, ALS1, EC:1.15.1.1, homodimer, hSod1

验证数据展示

  • Purity of Recombinant Human SOD1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human SOD1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human SOD1 protein Ala2-Gln154 (Accession# P00441) with a His tag at the N-terminus.
基因ID 6647
蛋白编号 P00441
预测分子量 19.9 kDa
SDS-PAGE 18-22 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) (SOD1, synonyms: ALS, SOD, ALS1, IPOA) binds copper and zinc ions and is one of two isozymes responsible for destroying free uperoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis.

参考文献:

1.J M McCord. et al. (1969). J Biol Chem. 244(22):6049-55.
2.Karin Forsberg. et al. (2010). PLoS One. 5(7):e11552.
3.Zhi Feng Lin. et al. (2013). Biochem Biophys Res Commun. 441(1):191-5.