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Recombinant human FGFR2(IIIc) protein (C-6*HIS)

种属

Human

纯度

>90 %, SDS-PAGE

标签

C-6*HIS

生物活性

EC50: 4-17 ng/mL

Cat no : Eg1265

Print datasheet

Synonyms

FGFR2, BEK, BFR 1, CD332, CEK3

验证数据展示

  • Immobilized Human FGFR2 (His tag) at 2 μg/mL (100 μL/well) can bind Human FGF1 (rFc tag) with a linear range of 4-17 ng/mL.

    Immobilized Human FGFR2 (His tag) at 2 μg/mL (100 μL/well) can bind Human FGF1 (rFc tag) with a linear range of 4-17 ng/mL.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Immobilized Human FGFR2 (His tag) at 2 μg/mL (100 μL/well) can bind Human FGF1 (rFc tag) with a linear range of 4-17 ng/mL.
来源 HEK293-derived Human CD28 protein Arg22-Glu377 (Accession# P21802-1) with a human IgG1 Fc tag at the C-terminus.
基因ID 2263
蛋白编号 P21802-1
预测分子量 40.3 kDa
SDS-PAGE
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

FGFR2 (Fibroblast growth factor receptor 2) is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis. Ligand binding leads to the activation of several signaling pathway, such as RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP Kinase signaling pathway, as well as the AKT1 signaling pathway. Mutations in the gene of FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.

参考文献:

1.Eswarakumar VP, et al. (2005). Cytokine Growth Factor Rev. 16(2):139-149.
2.Pike, KG. (2017). Topics in Medicinal Chemistry. 8.
3.Azoury SC, et al. (2017). Int J Biol Sci. 13(12):1479-1488.