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Recombinant Human CSF2RB protein (rFc Tag)

ED50

/

Species

Human

Purity

>90 %, SDS-PAGE

GeneID

1439

Accession

P32927-1

Cat No : Eg1662

Print datasheet

Synonyms

CSF2RB,CD131,CDw131,GM-CSF/IL-3/IL-5 receptor comm

验证数据展示

  • Purity of Recombinant Human CSF2RB was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CSF2RB was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Technical Specifications

Purity >90 %, SDS-PAGE
Endotoxin Level <1.0 EU/μg protein, LAL method
Biological Activity 
Not tested
Source HEK293-derived Human CSF2RB protein Trp17-Trp443 (Accession# P32927-1) with a rabbit IgG Fc tag at the C-terminus.
Predicted Molecular Mass 77.9 kDa
SDS-PAGE 75-100 kDa, reducing (R) condition
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

CSF2RB, also known as CD131, IL3RB, IL5RB, SMDP5, and CDw131, is a gene in humans that encodes the beta chain of the receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF), as well as IL-3 and IL-5. The protein is a transmembrane receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. In unstimulated conditions, CSF2RB interacts constitutively with JAK1, and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PMID: 1495999; 9516124).

References:

1. Tavernier J. et al. (1992). Proc Natl Acad Sci U S A. 89(15):7041-7045.
2. Ogata N. et al. (1998). Blood. 91(7):2264-2271.