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Recombinant Human SLAM/CD150 protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1702

Print datasheet

Synonyms

SLAMF1, CD150, IPO 3, IPO-3, SLAM

验证数据展示

  • Purity of Recombinant Human SLAM was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human SLAM was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human SLAM protein Ala21-Pro237 (Accession# Q13291-1) with a His tag at the C-terminus.
基因ID 6504
蛋白编号 Q13291-1
预测分子量 25.4 kDa
SDS-PAGE 38-50 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Signaling lymphocytic activation molecule (SLAM, also known as SLAMF1 or CD150) is a glycoprotein found on the surface of T, B, natural killer, and dendritic cells. The extracellular domain of CD150 serves as a receptor for the measles virus, and CD150 acts as a co-activator on T and B cells (PMID: 11486275). SLAM is constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation (PMID: 7617038). SLAM is involved in T cell stimulation and cytokine production, and may play an important role in the regulation of immune responses to pathogens (PMID: 30366106).

参考文献:

1. Wang N. et al. (2001). Immunogenetics. 53(5):382-394.
2. Cocks BG. et al. (1995). Nature. 376(6537):260-263.
3. Yigit B. et al. (2019). Clin Immunol. 204:3-13.