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Recombinant Human KIR2DL4 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1895

Print datasheet

Synonyms

CD158 antigen-like family member D, CD158D, G9P, Killer cell immunoglobulin-like receptor 2DL4, KIR 103AS

验证数据展示

  • Purity of Recombinant Human KIR2DL4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human KIR2DL4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human KIR2DL4 protein His24-His242 (Accession# Q99706-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 3805
蛋白编号 Q99706-1
预测分子量 50.3 kDa
SDS-PAGE 52-68 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells that regulate their responsiveness to signals received from their environment. Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4, also known as CD158D and KIR103AS) is an unusual member of the KIRs family, which activates the cytotoxicity of NK cells. KIR2DL4 has two immunoglobulin domains and a single immunoreceptor tyrosine-based inhibition motif (ITIM) in the cytoplasmic tail with weak inhibitory potential.

参考文献:

1. Sumati Rajagopalan, Eric O Long. (2012). Front Immunol. Aug 20:3:258.
2. Mathias Faure, Eric O Long. (2002). J Immunol. Jun 15;168(12):6208-14.
3. Sumati Rajagopalan, et al. (2006). PLoS Biol. Jan;4(1):e9.
4. Akiko Kikuchi-Maki, et al. (2003). J Immunol. Oct 1;171(7):3415-25.