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Recombinant Human CD83 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2033

Print datasheet

Synonyms

CD83, B cell activation protein, B-cell activation protein, BL11, CD83 antigen

验证数据展示

  • Purity of Recombinant Human CD83 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD83 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CD83 protein Thr20-Ala143 (Accession# Q01151) with a rabbit IgG Fc tag at the C-terminus.
基因ID 9308
蛋白编号 Q01151
预测分子量 43.3 kDa
SDS-PAGE 42-60 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD83 is a member of the immunoglobulin (Ig) superfamily, consisting of an extracellular V-type Ig-like domain, a transmembrane domain, and a cytoplasmic tail. CD83 is one of the most prominent markers for fully matured dendritic cells (DCs). It is also found on the surface of other activated hematopoietic cells, including lymphocytes, monocytes, macrophages, and neutrophils. CD83 regulates the maturation, activation, and homeostasis of numerous immune cells. CD83 can also expressed as a soluble form. Soluble CD83 can bind to DCs and inhibit their maturation.

参考文献:

1. Alexander T Prechtel, Alexander Steinkasserer. (2007) Arch Dermatol Res. May;299(2):59-69.
2. Ziduo Li, Xinsheng Ju, et al. (2019) Front Immunol. Jun 7:10:1312.
3. Linda Grosche, Ilka Knippertz, et al. (2020) Front Immunol.  Apr 17:11:721.
4. Matthias Lechmann, Elisabeth Zinser, et al. (2002) Int Arch Allergy Immunol. Oct;129(2):113-8.