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Recombinant Human CD68 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2061

Print datasheet

Synonyms

CD68, CD68 molecule, GP110, Macrosialin, SCARD1

验证数据展示

  • Purity of Recombinant Human CD68 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD68 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CD68 protein Asn22-Ser319 (Accession# P34810-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 968
蛋白编号 P34810-1
预测分子量 60.8 kDa
SDS-PAGE 80-110 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD68 is a 110 kDa transmembrane glycoprotein widely expressed in monocyte cell types, such as macrophages, microglia, and osteoclasts. It is located at the lysosome and plasma membrane and is essential in various physiological and pathological processes, including atherosclerosis formation, inflammation and auto-immunity, bone-resorbing promotion, and tumor progression. It participates in the cellular response to lipopolysaccharide/oxidized low-density lipoprotein particle stimulus and negative regulation of dendritic cell antigen processing and presentation.

参考文献:

1. C L Holness, et al. (1993) Blood. 81(6):1607-1613.
2. Maria C de Beer, et al. (2003) J Lipid Res. 44(4):674-685.
3. Li Song, et al. (2011) J Lipid Res. 52(8):1542-1550.
4. Jason W Ashley, et al. (2011) PLoS One. 6(10):e25838.
5. Gunnar Steinert, et al. (2014) Cancer Res. 74(6):1694-1704.
6. Giuseppe Troiano, et al. (2019) Oral Oncol. 93:66-75.