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Recombinant Human CD63 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2064

Print datasheet

Synonyms

CD 63, CD63 antigen, Limp1, Lysosomal-associated membrane protein 3, Lysosome integral membrane protein 1

验证数据展示

  • Purity of Recombinant Human CD63 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD63 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CD63 protein Ala103-Val203 (Accession# P08962-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 967
蛋白编号 P08962-1
预测分子量 37.8 kDa
SDS-PAGE 42-58 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD63 is a 30-60 kDa lysosomal membrane protein that belongs to the tetraspanin family. This protein plays many important roles in immuno-physiological functions. It mediates signal transduction events that play a role in the regulation of cell development, activation, growth, and motility. CD63 is expressed on activated platelets, thus it may function as a blood platelet activation marker. CD63 is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. The CD63 tetraspanin is highly expressed in the early stages of melanoma and decreases in advanced lesions, suggesting it as a possible suppressor of tumor progression. Deficiency of this protein is associated with Hermansky-Pudlak syndrome.

参考文献:

1. Ki-Kyung Jung, et al. (2006) EMBO J. Sep 6;25(17):3934-42.
2. Guillaume van Niel, et al. (2011) Dev Cell. Oct 18;21(4):708-21.
3. Maaike S Pols, Judith Klumperman. (2009) Exp Cell Res. May 15;315(9):1584-92.
4. D O Azorsa, et al. (1991) Blood. Jul 15;78(2):280-4.
5. M Nishibori, et al. (1993) J Clin Invest. Apr;91(4):1775-82.Maaike S Pols 1, Judith Klumperman