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Recombinant Human LAIR1 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2329

Print datasheet

Synonyms

LAIR1, CD305, hLAIR1, LAIR 1, LAIR-1

验证数据展示

  • Purity of Recombinant Human LAIR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human LAIR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human LAIR1 protein Gln22-His163 (Accession# Q6GTX8-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 3903
蛋白编号 Q6GTX8-1
预测分子量 44.8 kDa
SDS-PAGE 45-60 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes. It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor. Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1.

参考文献:

1. Meyaard L. et al. (1997) Immunity. 7(2):283-290.
2. Meyaard L. et al. (1999) J Immunol. 162(10):5800-5804.
3. Lebbink RJ. et al. (2006) J Exp Med. 203(6):1419-1425.
4, Rygiel TP. et al. (2011) Mol Immunol. 49(1-2):402-406.