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Recombinant human GPR56 protein (rFc Tag)

ED50

/

Species

Human

Purity

>90 %, SDS-PAGE

GeneID

9289

Accession

Q9Y653-1

Cat No : Eg2478

Print datasheet

Synonyms

GPR56,ADGRG1,ADGRG1 CT,ADGRG1 C-terminal fragment,

验证数据展示

  • Purity of Recombinant Human GPR56 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human GPR56 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Technical Specifications

Purity >90 %, SDS-PAGE
Endotoxin Level <1.0 EU/μg protein, LAL method
Biological Activity 
Not tested
Source HEK293-derived Human GPR56 protein Arg26-Asn171 (Accession# Q9Y653-1) with a rabbit IgG Fc tag at the C-terminus
Predicted Molecular Mass 42.7 kDa
SDS-PAGE 45-55 kDa, reducing (R) condition
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

GPR56 belongs to the adhesion family of G protein-coupled receptors (GPRs), is a receptor involved in cell adhesion and probably in cell-cell interactions, and mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. GPR56 binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. GPR56 Plays a critical role in cancer progression by inhibiting VEGFA production thereby inhibiting angiogenesis through a signaling pathway mediated by PRKCA.

References:

1. Rong Luo, et al. (2012) PLoS One. 7(1):e29818.
2. Lei Xu, et al. (2006) Proc Natl Acad Sci U S A. 103(24):9023-8.
3. Liquan Yang, et al. (2011) Cancer Res. 71(16):5558-68.