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Recombinant human GPR56 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

C-rFc

生物活性

未测试

Cat no : Eg2478

Print datasheet

Synonyms

GPR56, ADGRG1, ADGRG1 CT, ADGRG1 C-terminal fragment, ADGRG1 NT

验证数据展示

  • Purity of Recombinant Human GPR56 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human GPR56 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human GPR56 protein Arg26-Asn171 (Accession# Q9Y653-1) with a rabbit IgG Fc tag at the C-terminus
基因ID 9289
蛋白编号 Q9Y653-1
预测分子量 42.7 kDa
SDS-PAGE 45-55 kDa, reducing (R) condition
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

GPR56 belongs to the adhesion family of G protein-coupled receptors (GPRs), is a receptor involved in cell adhesion and probably in cell-cell interactions, and mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. GPR56 binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. GPR56 Plays a critical role in cancer progression by inhibiting VEGFA production thereby inhibiting angiogenesis through a signaling pathway mediated by PRKCA.

参考文献:

1. Rong Luo, et al. (2012) PLoS One. 7(1):e29818.
2. Lei Xu, et al. (2006) Proc Natl Acad Sci U S A. 103(24):9023-8.
3. Liquan Yang, et al. (2011) Cancer Res. 71(16):5558-68.