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Recombinant Human CD107a/LAMP1 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2611

Print datasheet

Synonyms

CD107a, LAMP1, CD107 antigen-like family member A, LAMP 1, LAMP-1

验证数据展示

  • Purity of Recombinant Human CD107a was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD107a was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CD107a protein Ala26-Ser381 (Accession# P11279-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 3916
蛋白编号 P11279-1
预测分子量 64.5 kDa
SDS-PAGE 75-105 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

LAMP1 (CD107a) is a heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis. Although LAMP1 is expressed largely in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane. Elevated LAMP1 expression at the cell surface has also been detected during platelet and granulocytic cell activation, as well as in some tumor cells. LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis.

参考文献:

1. Kundra R. et al. (1999) J Biol Chem. Oct 22;274(43):31039-31046. 
2. Parkinson-Lawrence. E. J. et al. (2005) Cell Immunol. 236(1-2):161-166.
3. Wang Q. et al. (2017) Oncol Lett. 14(4):4729-4735. 
4. Aktas E. et al. (2009) Cell Immunol. 254(2):149-154.