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Recombinant Human CD302 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2671

Print datasheet

Synonyms

CD302, BIMLEC, C type lectin BIMLEC, CD302 antigen, CD302 molecule

验证数据展示

  • Purity of Recombinant Human CD302 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD302 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CD302 protein Asp23-His168 (Accession# Q8IX05-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 9936
蛋白编号 Q8IX05-1
预测分子量 43.0 kDa
SDS-PAGE 40-50 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD302, also known as CD302 molecule, is a C-type lectin receptor (CLR) that plays a significant role in the immune system, particularly in cell adhesion, migration, endocytosis, and phagocytosis. CD302 is expressed mainly on myeloid phagocytes in human blood and has been implicated in the functional regulation of immune cells. As a CLR, CD302 recognizes molecular patterns expressed by exogenous and endogenous threats, capturing and internalizing antigens and mediating other important immune cell functions. In the liver, CD302 is expressed by hepatocytes, liver sinusoidal endothelial cells, and Kupffer cells. Among immune cells, myeloid cells such as macrophages, granulocytes, and myeloid dendritic cells (mDC) express the highest levels of CD302. CD302 is also considered a prognostic marker in various types of cancer, including Glioblastoma multiforme, Kidney renal clear cell carcinoma, and Lung adenocarcinoma. It has been detected in blood by mass spectrometry and proximity extension assays, suggesting its potential as a biomarker for certain diseases.

参考文献:

1. Masato Kato. et al. (2007). J Immunol. 179(9):6052-6063.
2. Tsun-Ho Lo. et al.(2016). J Immunol.197(3):885-898.
3. Birthe Reinecke. et al. (2022). J Virol. 96(7):e0199521.