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Recombinant Human Complement C2 protein (rFc Tag)

ED50

/

Species

Human

Purity

>90 %, SDS-PAGE

GeneID

717

Accession

P06681-1

Cat No : Eg3058

Print datasheet

Synonyms

C2,C3/C5 convertase,CO2,Complement C2,Complement C

验证数据展示

  • Purity of Recombinant Human Complement C2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) condition and stained using Coomassie blue.

    Purity of Recombinant Human Complement C2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) condition and stained using Coomassie blue.

Technical Specifications

Purity >90 %, SDS-PAGE
Endotoxin Level <1.0 EU/μg protein, LAL method
Biological Activity 
Not tested
Source HEK293-derived Human Complement C2 protein Ala21-Leu752 (Accession# P06681-1) with a rabbit IgG Fc tag at the C-terminus.
Predicted Molecular Mass 107.1 kDa
SDS-PAGE 90-125 kDa, reducing (R) condition
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Complement C2 is one of the serum glycoproteins in the classical and MBL pathways of complement activation. C2 is made up of three globular domains. The N-terminal domain, which constitutes the C2b segment, is made up of three short consensus repeats (SCRs). C2 deficiency carries an increased risk of developing systemic lupus erythematosus, recurrent infections and atherosclerosis.

References:

1. Tange CE, et al. (2018). Clin Chem Lab Med. Aug 28;56(9):1498-1506.
2. Huda R, et al. (2013). J Autoimmun. May;42:94-104. 
3. Budding K, , et al. (2021). Neurol Neuroimmunol Neuroinflamm. Nov 10;9(1):e1107. 
4. Laich A, et al. (2022). Immunobiology. May;227(3):152225.