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Recombinant Mouse CD44 protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3159

Print datasheet

Synonyms

CD44 antigen, CDw44, CSPG8, ECMR III, ECMR-III

验证数据展示

  • Purity of Recombinant Mouse CD44 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse CD44 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse CD44 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse CD44 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse CD44 protein Gln25-Thr224 (Accession# A2APM2) with a rabbit IgG Fc tag at the C-terminus.
基因ID 12505
蛋白编号 A2APM2
预测分子量 48.2 kDa
SDS-PAGE 60-75 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD44 is a cell surface adhesion receptor that plays a crucial role in various biological processes, including cell-cell interactions, cell-matrix adhesion, cell migration, and signaling. It serves as a receptor for hyaluronan (HA) and has been implicated in several other ligand interactions, including osteopontin (OPN), collagens, and matrix metalloproteinases. CD44 is highly expressed in many cancers and is known to regulate metastasis by interacting with extracellular matrix ligands, promoting migration and invasion processes involved in metastases. It also has been identified as a marker for cancer stem cells and immune cells.

参考文献:

1.Senbanjo LT. et al. (2017). Front Cell Dev Biol. 5:18.
2.Xu Y. et al. (2024). MedComm (2020). 5(6):e554. 
3.Xu H. et al. (2020). Exp Hematol Oncol. 9(1):36.