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Recombinant Human IL-10RB protein (rFc Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3446

Print datasheet

Synonyms

IL10RB, CDW210B, CRF2 4, CRF2-4, CRFB4

验证数据展示

  • Purity of Recombinant Human IL-10RB was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human IL-10RB was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human IL-10RB was greater than 90% as determined by SEC-HPLC.

    The purity of Human IL-10RB was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human IL-10RB protein Met20-Ser220 (Accession# Q08334) with a rabbit IgG Fc tag at the C-terminus.
基因ID 3588
蛋白编号 Q08334
预测分子量 49.8 kDa
SDS-PAGE 60-80 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in maintaining immune system balance. IL-10 signals through a receptor complex consisting of two molecules of the IL-10R alpha-chain (IL-10RA) and two molecules of the accessory IL-10R beta-chain (IL-10RB). IL-10RA and IL-10RB are members of the type II cytokine receptor family. IL-10RB, also known as IL-10R2 or CDw210b, is the signaling subunit of the IL-10R complex and is constitutively expressed in a variety of cell types. Binding of IL-10 to the IL-10R complex leads to JAK1- and TYK2-mediated phosphorylation of STAT3. IL-10RB is also shared by several other cytokines, including IL22, IL-26, IFN-γ, IL-28A/B and IL29.

参考文献:

1.Glocker EO, et al. (2011). Ann N Y Acad Sci. 1246:102-7. 
2.Shouval DS, et al. (2014). Adv Immunol. 122:177-210. 
3.Moore KW, et al. (2001). Annu Rev Immunol. 19:683-765. 
4.Donnelly RP, et al. (1999). J Interferon Cytokine Res. 19(6):563-73. 
5. Glocker EO, et al. (2011). Ann N Y Acad Sci. 1246:102-7.