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(-)-Anonaine

(-)-Anonaine 可从木兰科和安妮科的几个物种中提取出来，具有抗疟、抗菌、抗真菌、抗氧化、抗癌、抗抑郁和血管舒张的活性。(-)-Anonaine 通过 Bax 和 caspase 依赖性途径诱导人类宫颈癌（HeLa）细胞的凋亡，诱导 DNA 损伤并抑制人类肺癌 h1299细胞的生长和迁移。

CAS号

1862-41-5

分子式

C17H15NO2

主要靶点

Antioxidant|Antifungal|Apoptosis|Parasite

仅限科研使用

Cat No : CM08094

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Synonyms

番荔枝碱

验证数据展示

  • CAS No.: 1862-41-5

    (-)-Anonaine
    CAS#: 1862-41-5

产品信息

(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces apoptosis in human cervical cancer (HeLa) cells, induces DNA damage and inhibits the growth and migration of human lung cancer h1299 cells through Bax and caspase-dependent pathways.

CAS号 1862-41-5
分子式 C17H15NO2
主要靶点 Antioxidant|Antifungal|Apoptosis|Parasite
主要通路 微生物学|氧化还原|凋亡
分子量 265.31
纯度 99.22%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 番荔枝碱

靶点活性

HepG2(cell):38.3 ± 2.3 μg/ml(CC50)|HepG2(cell):23.2 ± 2.7 μg/ml

体外活性

(-)-Anonaine (50-200 μM ; 24h ; ) exhibited significant inhibition to cell growth and migration activities on human lung cancer H1299 cells.[1] (-)-Anonaine (10-200 μM) significant nuclear damages of H1299 cells were observed treatment in a comet assay, whereas higher concentrations (6 and 30 mM) of (-)-anonaine concentrations were required to cause DNA damages in an in vitro plasmid cleavage assay.[1]

溶解度

DMSO:2.65 mg/mL (10 mM)

参考文献

1.Chen BH,et al. (-)-Anonaine induces DNA damage and inhibits growth and migration of human lung carcinoma h1299 cells. J Agric Food Chem. 2011 ; 59(6):2284-2290. 2.Chen CY, et al. (-)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells. Food Chem Toxicol. 2008 ; 46(8):2694-2702. 3.Lee JJ, et al. Effects of anonaine on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Molecules. 2008 ; 13(2):475-487. 4.Gontijo DC, et al. Antiplasmodial activity and cytotoxicity, isolation of active alkaloids, and dereplication of Xylopia sericea leaves ethanol extract by UPLC-DAD-ESI-MS/MS. J Pharm Pharmacol. 2019 ; 71(2):260-269. 5.Gontijo DC, et al. Antiplasmodial activity and cytotoxicity, isolation of active alkaloids, and dereplication of Xylopia sericea leaves ethanol extract by UPLC-DAD-ESI-MS/MS. J Pharm Pharmacol. 2019 ; 71(2):260-269.

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