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β-CGRP, human acetate

β-CGRP, human acetate 是降钙素肽之一，通过受体活性修饰蛋白 (RAMP) 和降钙素受体样受体 (CRLR) 的复合物发挥作用（对于 CRLR/RAMP1 和 CRLR，IC50：1 nM 和 300 nM /RAMP2 在单元格中）。

CAS号

TP2167

分子式

C164H271N51O50S3

主要靶点

CGRP Receptor

仅限科研使用

Cat No : CM18463

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Synonyms

CGRP-II (Human) (acetate)|β-CGRP, human acetate (101462-82-2 free)|Human β-CGRP acetate

验证数据展示

  • CAS No.: TP2167

    β-CGRP, human acetate
    CAS#: TP2167

产品信息

β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptor (CRLR) (IC50s: 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells).

CAS号 TP2167
分子式 C164H271N51O50S3
主要靶点 CGRP Receptor
主要通路 神经科学|G蛋白偶联受体
分子量 3853.46
纯度 99.35%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 CGRP-II (Human) (acetate)|β-CGRP, human acetate (101462-82-2 free)|Human β-CGRP acetate

靶点活性

CRLR/RAMP1, cell assay:1 nM |CRLR/RAMP2, cell assay:300 nM

体外活性

β-CGRP, human acts via a complex of the CRLR and RAMP, with IC50s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 300 nM and 130 nM in HEK293T and NG108-15 cells expressing CRLR and RAMP2 [1]. CGRP is a potent vasodilator and also exhibits pro- and -anti-inflammatory activity [2].

参考文献

1.McLatchie LM, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9.
2.Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2