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(-)-Epigallocatechin-3-(3''-O-methyl) gallate

(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) 是从茶叶中分离出的一种天然产物，具有很强的抗氧化、细胞毒性和抗菌活性，可增强蚀刻漂洗粘合剂与牙本质的粘合稳定性。

CAS号

83104-87-4

分子式

C23H20O11

主要靶点

Antibacterial|Antioxidant

仅限科研使用

Cat No : CM08438

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Synonyms

(-)-EGCG-3''-O-ME

验证数据展示

  • CAS No.: 83104-87-4

    (-)-Epigallocatechin-3-(3''-O-methyl) gallate
    CAS#: 83104-87-4

产品信息

(-)-Epigallocatechin-3-(3''-O-methyl) gallate is a natural product isolated from tea leaves with strong antioxidant, cytotoxic and antibacterial activity, which enhances the adhesive stability of etching rinsing adhesives to dentin.

CAS号 83104-87-4
分子式 C23H20O11
主要靶点 Antibacterial|Antioxidant
主要通路 微生物学|氧化还原
分子量 472.4
纯度 99.59%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 (-)-EGCG-3''-O-ME

靶点活性

COX-2:0.17±0.03μM

体外活性

(-)-Epigallocatechin-3-(3''-O-methyl) gallate (3″Me-EGCG) (0–12.5 μM; 30 min; 37 °C) showed scavenging effects in HaCaT cell and cell-free systems.[2] 3″Me-EGCG (6.25、12.5 μM) recovered cell viability and increased the expression of heme oxygenase 1 (HO-1) under H2O2 exposure.[2] 3″Me-EGCG (6.25、12.5 μM) protected keratinocytes and regulated the survival protein AKT1 under ultraviolet B (UVB) and sodium nitroprusside (SNP) exposure.[2]

参考文献

1.Kawase M, et al. Antioxidative activity of (-)-epigallocatechin-3-(3''-O-methyl)gallate isolated from fresh tea leaf and preliminary results on its biological activity. Biosci Biotechnol Biochem. 2000;64(10):2218-2220.
2.Kim E, et al. Antioxidant and Cytoprotective Effects of (-)-Epigallocatechin-3-(3″-O-methyl) Gallate. Int J Mol Sci. 2019;20(16):3993.
3.Deng X, et al. Magnetic ligand fishing combination with high-performance liquid chromatography-diode array detector-mass spectrometry to screen and characterize cyclooxygenase-2 inhibitors from green tea. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;973C:55-60.
4.Kagaya N, et al. Suppression of cytotoxin-induced cell death in isolated hepatocytes by tea catechins. Eur J Pharmacol. 2002;450(3):231-236.

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